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Pharmaceuticals

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Identification of molecular signals using static SIMS on powders

SIMS can be used to confirm the presence of a drug or to make brand identification where different formulations exist

Overview

SIMS can be used to confirm the presence of a drug or to make brand identification where different formulations exist; a branded product may contain additional substances or a counterfeit product could show contamination.

The presence of binding, dehydrating or filling agents can also provide a unique fingerprint. In the example below, Al and Na come from the pill forming material. The high sensitivity of the analyser allows very low beam currents to be employed, keeping below the static SIMS limit preserves the high mass fragments required for unequivocal identification.

Powder Analysis

Powders may be analysed using SIMS, both for bulk composition and core-shell structure. Powders can be mounted using either conductive adhesive tape, dispersion, pill formation or pressing into indium sheet.

Further Reading

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Interface-Dominated Growth of a Metastable Novel Alloy Phase 1.94 MB 46 downloads

Interface-dominated Growth of a Metastable Novel Alloy Phase. ...
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Instantaneous Surface Work Function Dependence of MCs+n Molecular Ion Emission Under... 1.94 MB 42 downloads

Instantaneous surface work function dependence of MCs+n molecular ion emission under...
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Optimisation of the connection between TA-MS systems together with improved data interpretation for TA-MS applications. 1.98 MB 47 downloads

Optimisation of the connection between TA-MS systems together with improved data...
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High-temperature oxidation of CrN/AlN multilayer coatings. 605.40 KB 37 downloads

High-temperature oxidation of CrN/AlN multilayer coatings. ...
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Formation of a tetragonal Cu3Au alloy at gold/copper interfaces. 1.94 MB 37 downloads

Formation of a tetragonal Cu3Au alloy at gold/copper interfaces. ...
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Evidence of multiple H+ ion desorption pathways with ESD of chemisorbed and multilayer water. 2.35 MB 42 downloads

Evidence of multiple H+ ion desorption pathways with ESD of chemisorbed and multilayer...
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Energetics of MCsn+ molecular ions emitted from Cs+ irradiated surfaces. 207.58 KB 42 downloads

Energetics of MCsn+ molecular ions emitted from Cs+ irradiated surfaces. ...
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End point detection in ion beam milling of YB2 Cu3 07 thin films. 4.15 MB 41 downloads

End point detection in ion beam milling of YB2 Cu3 07 thin films. ...
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Dependence of scattered ion yield on the incident energy: Ne+ on pure gallium and indium. 252.94 KB 41 downloads

Dependence of scattered ion yield on the incident energy: Ne+ on pure gallium and...