fbpx
Select Page

Pharmaceuticals

For further information and pricing, please get in touch with us.

Identification of molecular signals using static SIMS on powders

SIMS can be used to confirm the presence of a drug or to make brand identification where different formulations exist

Overview

SIMS can be used to confirm the presence of a drug or to make brand identification where different formulations exist; a branded product may contain additional substances or a counterfeit product could show contamination.

The presence of binding, dehydrating or filling agents can also provide a unique fingerprint. In the example below, Al and Na come from the pill forming material. The high sensitivity of the analyser allows very low beam currents to be employed, keeping below the static SIMS limit preserves the high mass fragments required for unequivocal identification.

Powder Analysis

Powders may be analysed using SIMS, both for bulk composition and core-shell structure. Powders can be mounted using either conductive adhesive tape, dispersion, pill formation or pressing into indium sheet.

Further Reading

Icon

Application of Secondary Ion Mass Spectrometry for Analysis of Decorative Coatings on Fancy Goods Accessories 1.33 MB 55 downloads

Application of Secondary Ion Mass Spectrometry for Analysis of Decorative Coatings...
Icon

Alkali-metal-based molecular-ion secondary ion mass spectrometry for precise quantitative analysis of low-dimensional materials without standards 3.01 MB 64 downloads

Alkali-metal-based molecular-ion secondary ion mass spectrometry for precise quantitative...
Icon

The crucial role of defect structure in understanding the electrical properties of spark plasma sintered antimony doped barium stannate 1.74 MB 89 downloads

The crucial role of defect structure in understanding the electrical properties of...
Icon

Silicon-doped β-Ga2O3 films grown at 1 μm/h by suboxide molecular-beam epitaxy 1.33 MB 106 downloads

Silicon-doped β-Ga2O3 films grown at 1 μm/h by suboxide molecular-beam epitaxy ...
Icon

Interaction of molecular oxygen ions with copper surface: features of the energy spectra of sputtered and backscattered ions 511.39 KB 105 downloads

Interaction of molecular oxygen ions with copper surface: features of the energy...
Icon

P-type conductivity in Sn-doped Sb2 Se3 2.64 MB 102 downloads

P-type conductivity in Sn-doped Sb2 Se3 ...
Icon

Controlling Li Dendritic Growth in Graphite Anodes by Potassium Electrolyte Additives for Li-Ion Batteries 3.75 MB 140 downloads

Controlling Li Dendritic Growth in Graphite Anodes by Potassium Electrolyte Additives...
Icon

Robust nonfullerene solar cells approaching unity external quantum efficiency enabled by suppression of geminate recombination 1.05 MB 111 downloads

Robust nonfullerene solar cells approaching unity external quantum efficiency...
Icon

Mitigating Structural Instability of High-Energy Lithium- and Manganese-Rich LiNixMnyCoz Oxide by Interfacial Atomic Surface Reduction 4.22 MB 110 downloads

Mitigating Structural Instability of High-Energy Lithium- and Manganese-Rich LiNixMnyCoz...
Icon

Towards x-ray waveguide formation upon ion irradiation of a Co thin film on Si(111) 1,011.83 KB 109 downloads

Towards x-ray waveguide formation upon ion irradiation of a Co thin film on Si(111) ...